Get in Mah Belly: Fun Size Food Facts

Gluten-Free Diet

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If food was fashion, Mugatu would most certainly agree, gluten is "so hot right now". Gluten-free diets have been proposed for a myraid of ailments - weight loss, depression, allergies, etc. It's even been proposed to be linked to autism. Heck even "Ms. Cyrus" is doing it? (citing celebrities, always smart) But is there any evidence for it? In short, no. Zilch.

Now I'm not talking about celiac disease/gluten-sensitive enteropathy. There's obviously plenty of data for it. That is a diagnosis that can be made with actual lab tests. However, gluten sensitivity is more of a catch-all phrase that has seen light more from pop culture than from medical literature. But that doesn't mean it's not real. Just that there is a lack of any evidence for it. 

Reasons for not doing gluten-free diets? There are some but they aren't the greatest in the world in my opinion.

When you take out wheat, rye, and barley from your diet you tend to have less exposure to vitamins such as folate, B12, and iron as well as fiber. But let's be honest, the demographic that are going gluten-free are those that have better access to fruits and vegetables. I have yet to see an urban underserved patient at my clinic come asking about gluten-free diets. The person who has enough resources and is dedicated enough to go gluten-free is typically one who will supplement their diet with other healthy, non-gluten options.

B12 - fish, beef, yogurt

Folate - beans, spinach, lentils

Iron - beef, chicken, spinach, lentils

So for me? If a patient asked about a gluten-free diet, the most important question would be "why?" Once any other source of pathology was ruled out for their symptom, I would be fine trying a gluten-free diet on top of other more evidence-based treatments. In the end, the biggest hit won't typically be to your health, it'll be to your wallet.

Verdict: As long as you're otherwise healthy and supplementing your diet, I'm cool with it.

Multivitamins

When I think of multivitamins, I think of my mom. I can instantly flashback to high school when every morning there would be a pink multivitamin sitting in a small container just waiting for me downstairs. It's always been good parenting 101 - take your vitamins. Well, as time has gone on and more and more data has come forth. That old adage is no longer as sound advice as you would have hoped.

Taking a look at the Centrum website, you can see there's quite a bit that goes into a typical multivitamin. There's a lot to take in but I'm going to try and break down the evidence first by specific vitamin and then by multivitamins as a whole. I'll be skipping Vitamin D because that's a completely different discussion. In addition, I'm only including the most up to date studies for Cochrane since they have changed so many times in the past 10 years.

• Vitamin A
  • 2012 Cochrane review: Possible increase in all-cause mortality (78 RCTs) [1]
• Vitamin E
  • 2012 Cochrane review: Possible increase in all-cause mortality (78 RCTs)
• Vitamin C
  • 2012 Cochrane review: NO increase in all-cause mortality (78 RCTs)
• Selenium
  • 2012 Cochrane review: NO increase in all-cause mortality (78 RCTs)
• Beta-carotene
  • 2012 Cochrane review: INCREASE in all-cause mortality (78 RCTs)
• Multivitamins
  • 2013 Meta-analysis: NO increase in all-cause mortality [2]
  • 2012 RCT (Physicians' Health Study II): NO increase in all-cause mortality for older men. Reduced cancer incidence only if hazard ratios were adjusted. [3]
  • 2011 large observational trial (Iowa Women's Health Study): 2.4% absolute risk increase in all-cause mortality in older females. [4]

Looking at the most recent evidence, there really isn't a good reason to take multivitamins or specific supplements if you're a nourished, healthy individual in the developed world. In the end, there's a possible risk of mortality increase with certain supplements or for certain demographics and it's just another pill you have to take every day.

Verdict: Don't take them unless you have a documented nutritional deficiency or live in an area with nutritional deficiencies.

Fish Oil

Fish oil - the multivitamin of the adult. If it's not your mother then it's probably a family member or friend that has told you to take fish oil supplements. Like all vitamins or supplements, fish oil has been proposed to protect the body in a number of ways. For the sake of time and my sanity, I'm just looking at coronary heart disease as it's the main indication.

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The first fish oil study was based off of the fact that Greenland Eskimos had low rates of coronary heart disease. Their high fish diet led them to do a 20 year observational study showing a 50%+ reduction in CHD in those who ate 30g of fish per day versus those who didn't. [5] This was bolstered by large meta-analysis of cohort and randomized trials in 2006, which found a 36% reduction in coronary deaths in those with "modest" fish consumption (1-2 servings/week). [6]

This leads us to the latest systematic review in JAMA 2012 that found that neither fish oil supplements nor eating extra servings of fish had any benefit with all-cause mortality, cardiac death, sudden death, MI, or stroke. [7] This was somewhat of a surprise since a healthy  number of the participants had pre-existing CHD. One caveat that people much smarter than myself found was that there was actually a statistically significant 10% reduction in cardiac death in those that consumed omega-3 supplements. However, this benefit disappeared once they adjusted comparisons. I decided not to look in depth into the comparisons because I'm out of ibuprofen.

Verdict: Jury is still out. In the meantime, probably safe to take fish oil supplements high in EPA and DHA. Better yet, just eat some fish.

Bonus: There is limited data on the effects of fish oil on healthy adults without CHD. Study due in 2016 may answer this.

Top 5: Bones Breaking, Bad

There are two constants in life. The first is that Seattle drivers will always be awful and the second is that people love lists. David Letterman does it, there are websites dedicated to it, and American sports fans crave it. It's a way of life here. So to feed your need for lists, I'll be starting up a new series called "Top 5". The Top 5 will be a list of what I personally consider to be the most important aspects to a certain topic. I'll be straying a bit from the more objective, evidence-driven blogs for a bit and giving you a heavy dose of subjective content that you'll most likely disagree with.

1. Fractures Suspicious of Child Abuse: Spidey sense

I'm kind of cheating here as this is more of a category then an actual fracture. This category is an entire talk/lecture/blog of its own but the take home point here is that whenever you have a child with a fracture, you should hone your inner spidey sense. The history is really where it's at as you'll want to take into account whether the child is ambulatory yet and whether the mechanism truly fits the fracture. For instance, a child who can't walk won't be likely to have a femoral fracture. Also, it's important to remember that if there is any suspicion of fracture, ordering a bone scan can help differentiate accidental vs non-accidental fractures (i.e. if you find a skull fracture after a rib fracture). Here are some of the most classic fractures of abuse.

• Rib fractures: Kid's ribs, just like all of their bones, are more flexible than adults. Unlike your geriatric patients, it takes a lot to cause a rib fracture. Without any history of serious trauma (MVA), it's highly unlikely for a child to have a rib fracture. One meta-analysis found a predictive probability of child abuse in pediatric rib fractures was 71%. [1] Also, it's much more predictive of possible abuse if there are multiple fractures in a row - when hands are placed on the ribs the fractures are seen where the thumbs overlay.

• Metaphyseal Corner fracture (MCF) or "Bucket Handle" fracture: Probably the most classic fracture of child abuse. MCF's are typically seen when limbs are pulled or twisted with force. Like with many pediatric fractures, it is highly suspicious of a child has a MCF when they are non-ambulatory. It's important to remember that these are often asymptomatic unless there is significant displacement of the fracture.

• Skull fractures: This is especially concerning in younger children (<2 years old), skull fractures are seen frequently in abused children but they aren't necessarily that specific for non-accidental trauma. Again, history is your friend here as asking about the mechanism of injury (height, surface, area of head landed on) will all help correlate the radiological findings. As a general rule of thumb, I found that a fall from less than 2 feet is highly unlikely to cause more than a linear skull fracture. More suspicious skull fracture findings include crossing suture lines, bilateral, branching and depressed.

2. Pelvic Fracture: The Open Book You Don't Want to Read

Now being Family Medicine physicians in an urban setting, we tend not to see as much acute trauma. But since this fracture has the highest risk for mortality on the list, it's probably poor form to miss it. Now I'm not talking about the ol' regular, atraumatic, geriatric pelvic fracture here. Those don't tend to have as much hemorrhage risk to them. I'm talking about high force, high velocity fractures (MVA, skiing/snowboarding, twerking). In a couple different case series it was found that 38.5 and 34 percent of patient's with pelvic fractures required transfusions. [2,3]. Mortality rates for pelvic fractures can vary from the more common acetabular fractures (3%) to open pelvic fractures (45%) [4,5]

The name of the game here is proper diagnosis, which entails a good history of mechanism of injury as well as a good exam (ecchymosis in the surrounding area, pain on palpation, vaginal/rectal exam for open fracture, and compression of the pelvis). External compression isn't something I have a ton of experience with but this very serious and professional looking trauma doc has a nice blog entry on it. Basically, compress AP compression type fractures and not lateral or vertical fractures. Take a look at the video below on proper sheeting technique. Although, it's not completely accurate because a lot of your trauma patients will have their pants cut through so you wouldn't be able to tuck the sheet into them..

 

3. Jones Fracture: The Unseen Fracture is the Deadliest

Five dollars for the first person who can tell me what the above is referencing. Jones fractures aren’t deadly but I couldn't resist using that quote. However, they are often unseen. Jones fractures probably wouldn't make many people's Top 5 but the reason I threw it in here was because we just see so many ankle injuries as primary care physicians.

The Ottawa ankle rules are in place to avoid unnecessary xrays, but also to help reinforce the important areas to look for in the foot. The 5th metatarsal is one of the imaging indications mainly to look at a Jones vs. a fifth metatarsal tuberosity fracture. The difference, albeit small, is important as the management can differ. Most non-displaced metatarsal tuberosity fractures can heal with conservative management but Jones fractures have a much lower likelihood of healing without surgical intervention. They can be very difficult to distinguish so getting some input from a radiologist or your favorite podiatrist (whattup Dr. Hale) can be helpful. When discussing treatment options, it’s important to note that up to 50% of acute Jones fractures will result in nonunion and that surgery has a much higher rate of symptom and fracture resolution long term. However, this all depends on your patient and their clinical and personal context.

For more on Jones fractures, check out this very nice AFP article found here. 

4. Scaphoid Fractures: Awristed Development

Scaphoid fractures are pretty much in the same category as Jones fractures. We don’t see a ton of them but we do have a lot of patients who fall onto outstretched hands. I like to think of myself when it comes to scaphoid fractures because the primary demographic is males aged 15-30 and I swear I had/have one myself. Every physician has their own specific sector of hypochodrisis and mine is this pain I have in my left wrist. I fell on my outstretched hand playing flag football a number of years ago and had quite a bit of pain at the time. I never thought much of it until this past 6 months where I had the recurrence of that pain but this time with no known trauma. Better with rest. Worst with working out, especially push ups and pull ups. I swear there was either nonunion or growing OA in that wrist.

Anyways, my little clinical vignette, albeit unlikely a fracture, shows the importance of proper diagnosis of the scaphoid fracture because if you miss it, it can result in nonunion or delayed union. Pain in the anatomical snuffbox is remarkably sensitive (~90%) but not very specific (40%). Xrays are even worse with reported sensitivity of 86%. For those grey areas when you suspect a fracture but don’t see one, this great AFP article recommends placing patients in a thumb spica and reevaluating in 2 weeks. Just remember me the next time your patient comes in with traumatic wrist pain!

5. Hip Fracture: I've Fallen and I Can't Get Up

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Finishing strong with the fracture, I for one, see the most often: the hip fracture.  With the US population aging at a rapid rate, you’ll undoubtedly have the pleasure of diagnosing many more of these in the future.

We don’t want to miss hip fractures for a variety of reasons. It gives a window into the prognostic future of the patient with one year mortality rates up to 20% and roughly 50% of those who lived independently prior to the hip fracture are unable to gain an independent lifestyle again. [6] With delayed diagnosis, it just gets worse as not only does adequate treatment get postponed but the frequency of of avascular necrosis or other complications increase. But really, the emphasis should be placed on fall prevention to begin with. Which I’m proud to say my colleagues in residency do very well.

Shout out to SFH residents.

Freestyle Friday: Nuts Save the Day

Who has time for an intro? It's the Christmas season. Enjoy some links!

• Maple thinks you might be driving a bit too fast.
• Science says nuts are healthy. Sprize.
• Your neutrophils in action. It's like a large, grotesk heat seeking missle in your blood.
• Lastly, an oldie but goodie. A gif of everyone's favorite crime fighter, Snackman. He's probably eating some nuts.